p130Cas is an essential transducer element in ErbB2 transformation
نویسندگان
چکیده
منابع مشابه
p130Cas is an essential transducer element in ErbB2 transformation.
The ErbB2 oncogene is often overexpressed in breast tumors and associated with poor clinical outcome. p130Cas represents a nodal scaffold protein regulating cell survival, migration, and proliferation in normal and pathological cells. The functional role of p130Cas in ErbB2-dependent breast tumorigenesis was assessed by its silencing in breast cancer cells derived from mouse mammary tumors over...
متن کاملFinite Element Modeling of an Ultrasonic Transducer
Ultrasonic transducers are integrated into the minimally invasive needles and catheters for medical diagnostic. There is a need for a model that can predict the behavior of the ultrasonic transducer. Many designers employ one dimensional analytic models, however due to certain limitations these models are not adequate to understand the entire performance of an ultrasonic transducer. Nowadays, f...
متن کامل[Is chromium an essential trace element in human nutrition?].
It has been recognized that chromium is an essential trace element associated with carbohydrate metabolism, and chromium deficiency causes an impaired glucose tolerance. Recently, however, Vincent et al. have reported that chromium is not an essential trace element. In the present report, the author evaluated the nutritional essentiality of chromium by reviewing several previous reports. In alm...
متن کاملThe p400 Complex Is an Essential E1A Transformation Target
Here, we report the identification of a new E1A binding protein complex that is essential for E1A-mediated transformation. Its core component is a SWI2/SNF2-related, 400 kDa protein (p400). Other components include the myc- and p/CAF-associated cofactor, TRRAP/PAF400, the DNA helicases TAP54alpha/beta, actin-like proteins, and the human homolog of the Drosophila Enhancer of Polycomb protein. An...
متن کاملZinc is an essential trace element for spermatogenesis.
Zinc (Zn) plays important roles in various biological activities but there is little available information regarding its functions in spermatogenesis. In our current study, we further examined the role of Zn during spermatogenesis in the Japanese eel (Anguilla japonica). Human CG (hCG) was injected into the animals to induce spermatogenesis, after which the concentration of Zn in the testis inc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fj.10-157347